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| | Characterize proteins in their natural state, study protein interactions in solutions, and optimize lead compounds |
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| | ProteomeLab XL-A/XL-IProtein Interaction Analysis System in SolutionIt is an important analytical tool for studying the physicochemical properties of biomolecules such as proteins, oligomers, colloids, etc. in solution, where the solution state refers to any detection environment that can fully meet the research needs. ProteomeLab XL-A/XL-I is applied to the study of sample heterogeneity, stoichiometry, self polymerization, and other aspects by detecting changes in sample molecular weight. This system is based on the principles of thermodynamics and fluid dynamics, and does not require standard samples. The ProteomeLab XL-A/XL-I protein interaction analysis system will enable you to achieve your research goals more quickly. |
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| | Product features of protein interaction analysis system in solution |
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| Multi detection system |
| | The ProteomeLab XL-A is equipped with a UV/Vis scanning detection system, ensuring sensitivity at low concentrations and optimizing detection selectivity based on the maximum light absorption of the sample. In addition to the UV/visible light detection system, XL-I model also adds an interferometric light detection system, which can measure the refractive index changes caused by changes in sample concentration. This not only improves detection accuracy, but also enables detection of a wider range of samples with a larger concentration range. XL-I can collect data sequentially from two detection systems, providing more information on protein properties in solution. |
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| Easy to operate |
| | The preparation of the sample is very simple, just add different volumes of samples and reference materials to the sample pool, and then start the detection. The system can analyze up to 28 samples at once, without being limited by the pH value, ion strength, or concentration of the solution. After the operation is completed, the sample can be recycled for testing in other experiments. |
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| Flow pool component |
| | Pre installed flow cell components can be used to directly add samples and reference materials without the need to assemble the sample cell. The cleaning holes on the flow cell facilitate the cleaning of the sample cell and facilitate its use in the next experiment. |
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| | Because of ProteomeLab ™ The measurement of XL-A/XL-I is based on the laws of thermodynamics and fluid mechanics, so there is no need for standards |
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| | Application examples |
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| | Intermolecular interaction |
| | ProteomeLab XL-A/XL-I can help you analyze whether a small molecule binds to a target protein. In common examples, hormone receptor interactions require analysis |
| | Does the small molecule inhibitor (green square) bind to the receptor (A) or hormone (B). Small molecule inhibitors only have light absorption at 321nm. Due to their small molecular weight, they do not |
| | Can measure its settlement. If it binds to a protein, the absorption at 321nm wavelength decreases as the bound protein settles at the corresponding molecular weight. The image on the left hand shows |
| | The settling equilibrium of the mixture of small molecule inhibitors and receptors indicates that the compound does not bind to the receptor, as the light absorption spectrum of the inhibitor (red) does not show significant curvature. The image on the right hand |
| | There is a significant bending, indicating that the compound binds to the hormone. |
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| | Heterogeneity of proteins |
| | The analysis of sample heterogeneity is an important part of the entire process analysis, quality assurance, and quality control. The peaks in the distribution chart intuitively describe the heterogeneity of the sample. The position of each peak |
| | Corresponding to its settlement coefficient, the peak area represents the amount of sample. |
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| | If you want to learn more about this product or need professional personnel to answer your professional questions about product performance, after-sales service, etc., please do so immediatelyJoin Us |
