Wet granulation stirring torque rheometer

▲Reduce the development time of the formula.

▲Optimize formula performance.

▲Develop a 'scale based' production strategy.

▲Real time monitoring of product batches.

▲Research powder/The relationship between adhesives

Introduction

CalevaMixing torque rheometer（MTR3）It is a great tool for researching valuable formulas. In the mixing tank of high shear wet granulation, a torque measurement system is provided to monitor the torque generated in real time. Therefore, it is designed as follows:

⇒Tools for formula research

⇒Tools for process and scale development

⇒Quality control and monitoring equipment for the production process

⇒Tools for basic scientific research

Unique equipment, easy to operate and surprisingly useful

Main applications

▲Greatly improve the speed of formula development and testing, just use100The relationship between powder and binder can be studied by taking samples, and the optimal binder ratio and mixing time can be determined within one hour.

▲Ensure formula optimization to compensate for differences between batches. Changes in the source of excipients and internal components of batches may affect the characteristics and quality of the formula, and these differences can be further quantified and resolved in the early stages.

▲A large-scale expansion program can be developed in the process, using quantitative data for production; A scalable approach based on small-scale quantitative data can save time and development costs for each formula.

▲Conventional batch product consistency testing is completed within a few minutes as a quality prediction for the final product, eliminating the need for lengthy intermittent shutdowns and increasing equipment costs.

▲Quantifying the relationship between different adhesives and mixing times in both simple and complex formulations as a fundamental research toolMTR3It will help verify the fundamental issues of already used, intuitive, and complex formula development.

Configuration and Control

The required workspace is approximately400 x 500Millimeters, plusPCThe SpaceMTR-3The weight is35About kilograms. standardPCThere must be two available communication ports, and at least the minimum computer specifications must be provided as required; All operations are completed throughPCControl the software window on.

Operational requirements

Single phase power supply（110-240V）, as well as the required standardsPCIt is the only requirement for this device. If you have any questions or special requirements, please contact us for consultation.

Output and efficiency

MTR-3Easy to operate, with a little training for operators, results can be quickly obtained. The optional adhesive automatic addition system can be set to automatic operation mode, allowing all experiments to run automatically and data to be collected automatically. The results can be viewed or exported through the device's random softwareExcelElectronic spreadsheets for additional analysis or storage. The generated data can significantly reduce the time required for formula development, not only improving the efficiency of formula development, but also providing more optimized formulas.

Optional accessories

• Sample tank heating/Cooling system for precise temperature control.

Upgrade adhesive addition to a fully automated adhesive addition process.

•1/2The tank and agitator options allow for further reduction in product demand to achieve each test.

The extrusion head option is suitable for small-scale screw extrusion tests.

Software upgrade complies with21CFR Part 11requirement.

If you have any special needs, please contact us.

Technical Reference

fromCalevaA complete technical reference list can be obtained, and the most important references are:

Parker, Rowe, and Puqiang, stirring torque rheometer-A new method for quantifying the characteristics of wet granulation. International Medical Technology2（8），50-62（1990）.

Rovi and Parker, stirring torque rheometer–Upgrade European pharmaceutical technology6（3），27-36（1994）.

Rowe, stirring torque rheometer–Latest Developments in European Pharmaceutical Technology8（8），38-48（1996）.

Copies of these references, as well as additional information, can be obtained from us.